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172 In a rat model, alpha-lipoic acid and glutathione reduced some of the adverse changes in blood parameters, including drops in red blood cell number and size as well as reductions in hemoglobin concentration brought about by intoxication with lead, cadmium, or copper

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When NCOA4 expression is upregulated, it recognizes and binds to ferritin heavy chain 1 (FTH1) and mitochondrial ferritin (FTMT), interacting with autophagy-related factors and primary autophagosomes to form autophagosomes for lysosomal degradation, thereby releasing large amounts of Fe 2+ and forming the LIP

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